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Imp-1/crd-bp function

Witryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis. of human colorectal cancer, a disease in which the activation of. b ... (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. J. Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD …

C‐MYC and IGF‐II mRNA‐binding protein (CRD‐BP/IMP‐1) in …

Witryna18 maj 2010 · Molecular Function: translation regulator activity Source:BHF-UCL. 1 publication. ... IMP-1; IMP1. Alternative names. Coding region determinant-binding … WitrynaPlasmid pIS1 IMP-1 long UTR from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 UTR and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. easys profesia https://delenahome.com

IMP-1 Recombinant Protein - Cat. No. 39-901 ProSci

Witryna7 sty 2011 · CRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper cell adhesion, cytoplasmic spreading, and invadopodia formation through its binding to the 3′UTR of CD44 mRNA and stabilization of the mRNA. In … WitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … WitrynaPlasmid pMSCV PIG IMP-1-long-mut from Dr. David Bartel's lab contains the insert IGF-II mRNA-binding protein 1 and is published in Cell. 2009 Aug 21. 138(4):673-84. ... (a.k.a. CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1) ... Long means that all functional alternative polyadenylation signals have been deleted. community level cdc county

C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in …

Category:Expression of oncofetal RNA‐binding protein CRD‐BP/IMP1 …

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Imp-1/crd-bp function

Transcriptional Regulation of CRD-BP by c-myc: Implications for c …

WitrynaIMP-1 Recombinant Protein (Cat. No. 39-901) has been validated for use in E and WB. ... ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding protein 1, Coding region determinant ... The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". cookielawinfo … Witryna15 cze 2006 · It is shown that β-catenin stabilizes the mRNA encoding the F-box protein βTrCP1, and the RNA-binding protein CRD-BP is identified as a previously unknown …

Imp-1/crd-bp function

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Witryna10 paź 2016 · CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. Witryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, …

WitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul... Witryna19 lis 2004 · Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism …

WitrynaCRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1[1] and the human forms of the protein … Witryna6 paź 2001 · CRD‐BP/IMP‐1 belongs to a family of RNA‐binding proteins containing 2 RRMs and 4 KH domains; it plays a role in the posttranscriptional control of both …

Witryna5 maj 2008 · Inhibition of β-TrCP function sensitizes human ... (2001). C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. ... (2007). CRD-BP shields c-myc and ...

Witryna31 lip 2009 · Similarly, the half-life of a GBG mutant lacking an miR-183-binding site was not affected by CRD-BP, as compared to GBG containing the wild-type 577–1182 nt fragment of βTrCP1 (Figure 3 E). Knockdown of CRD-BP reduced expression of βTrCP1, but failed to do so when the function of miR-183 was inhibited (Figure 4 A). community level by countyWitryna20 cze 2024 · The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila. Mech. Dev. (2000) ... on the understanding of the oncogenic mechanism of CRD-BP as well as in the future design of inhibitors against CRD-BP function.Coding region determinant-binding protein (CRD-BP) interacts physically … easy sproutWitryna19 lis 2004 · CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that bind to the 5′-untranslated region of IGF-II leader 3 mRNA. ... In summary, our results revealed a novel function for CRD-BP in cell proliferation involving an IGF-II-dependent mechanism that appears independent of … community levels cdc covid